*{
    padding: 0;
    margin: 0;
}

.pc { display: block !important; }
.sp { display: none !important; }

h1 img{
    width: 100%;
}

header{
    z-index: 10000;
    top: 0;
    left: 0;
    width: 100%;
    height: 75px;
    right: 20px;
    margin: 1% 0 0 0;
    position: fixed;
}

a{
    text-decoration: none;
}

.header{
    display: flex;
    justify-content: space-between;
    margin: 0 0;
    background: rgba(255,255,255,0.8);
    border-radius: 50px;
    right: 15px;
    left: 15px;
    position: absolute;
}

.header_a{
    font-size: 1em;
    margin: auto 0;
    -webkit-box-flex: 1;
    -ms-flex: 1 1 auto;
    flex: 1 1 auto;
}

.header_a ul{
   list-style: none;
   display: flex;
    padding-right: 100px;
    padding-bottom: 1px;
    -webkit-box-pack: start;
    justify-content: flex-start;
    -webkit-box-align: center;
    align-items: center;
    justify-content: space-between;
}

.l-header_nav_item:not(:first-child){
    margin-left: 4px;
}

.header_icon{
    padding: 1em 0.5em 0.5em 0.5em;
}

.header_a_padding{
    padding-left: 0.3em;
}

.header a {
    color: #000;
    font-size: 1.5vw;
}
  
.header a:hover {
    text-decoration: underline;
    text-decoration: none;
}

.logo{
    width: 20%;
}

.main_logo{
    display: flex;
    text-align: center;
    padding: 0 1em 0 1em;
    margin: auto 0;
}

.main_logo_title{
    padding-left: 0.5em;
}

.main_logo_big_title{
    font-size: 0.95em;
}

.main_logo_small_titlt{
    font-size: 0.8em;
}

.header_icon img{
    width: 20%;
}

.main{
    max-width: 1920px;
    margin: auto;
    overflow: hidden;
}

.header,.explanation_content,.director_content,.NMN_difference_content{

}

.header_icon img{
    width: 38px;
}




.explanation_content_back_color{
    background: linear-gradient(#fff, #dad3c1);
}

.mail_icon{
    padding: 0 1em 0 1em;
}

h2,h3,.explanation_content_title,.font-color,.explanation_content_summarize,
.NMN_difference_left_title,.NMN_difference_right_title,
.NMN_difference_left_p,.NMN_difference_right_p,.difference_summarize_p,.header a,
.patient_content_h5,.patient_voice_age,.patient_voice_p1,.patient_voice_p2,
.director_content,.NMN_effect_content,.flow_content,.price_content,.detail_content,footer{
    font-family: "游明朝体" , "YuMincho";
}

h2{
    font-size: 3.75em;
    line-height: 1.3em;
}

h3{
    font-size: 2.5em;
}

.explanation_content{
    padding: 1em 0;
}

.explanation_content_title{
    font-size: 3.7em;
    text-align: center;
    padding-bottom: 1em;
    line-height: 1;
}

.small_title{
    font-size: 0.666666em;
}

.explanation_content_h2{
    display: flex;
	align-items: center;
}

.explanation_content_h2:after {
	content: "";
	flex-grow: 1;
	height: 2px;
	display: block;

}

.explanation_content_h2:after {
	margin-left: .4em;
	background: #dad3c1;
}

.explanation_content_up{
    display: flex;
    justify-content: space-between;
    position: relative;
}

.explanation_content_sentence{
    width: 60%;
}

.explanation_content_img{
    width: 30%;
}

.font-color{
    color: #8c7c4d;
}

.explanation_content_h3{
    padding: 1em 0;
    line-height: 1.4em;
}

.explanation_content_up_p{
    font-family:"Yu Gothic Medium", "游ゴシック Medium", YuGothic, "游ゴシック体", "ヒラギノ角ゴ Pro W3", "メイリオ", sans-serif;
    font-size: 1.625em;
    padding-bottom: 2em;
}

.explanation_content_up_p_bottom{
    margin-bottom: 5%;
    padding: 0 4em;
}

.img_under{
    position: absolute;
    right: 0;
    width: 25%;
}

.img_up{
    position: absolute;
    top: 23%;
    right: 13%;
    width: 25%;
}

.gene_content{
    padding-top: 3em;
    display: flex;
}

.gene_content img{
    height: 100%;
    padding-left: 2em;
}

.gene_content_p{
    width: 65%;
}

.gene_content_title{
    padding-bottom: 1em;
}

.explanation_content_title_span{
    font-size: 0.83334em;
}

.explanation_content_title_color{
    color: #8c7c4d;
}




.arrow{
    display: block;
    margin: 0 auto;
    width: 18%;
}

.title_down{
    padding-bottom: 0.5em;
    line-height: 1.4em;
}

.NMN_difference_content{
    margin: -2em auto 1em auto;
    padding: 1em 0 0 0;
}

.explanation_content_left_padding{
    padding: 1em 0 1em 2em;
    padding-top: 30px;
    margin-top: -30px;
}

.NMN_difference_left p:last-child{
    margin-bottom: 0%;
}

.line_p{
    text-align: center;
    padding: 1em 0 3em 0;
}

.line{
    display: inline;
    border: 2px solid #8c7c4d;   
    padding: 1em 0;
}

.NMN_everyday_content_explanation{
    display: flex;
    position: relative;
}

.NMN_everyday_content{
    padding: 1em 0 1em 2em;
}

.p_width{
    width: 64%;
    font-size: 1.4em;
}

.NMN_everyday_content_explanation img{
    position: absolute;
    right: 0%;
    width: 30%;
}

.NMN_everyday_content_h2{
    display: flex;
	align-items: center;
}

.NMN_everyday_content_h2:after {
	content: "";
	flex-grow: 1;
	height: 2px;
	display: block;

}

.NMN_everyday_content_h2:after {
	margin-left: .4em;
	background: #8c7c4d;
}



.explanation_content_summarize{
    margin: 0 auto;
    font-size: 3.5em;
    text-align: center;
    padding-bottom: 1.5em;
    position: relative;
}

.summarize_small{
    font-size: 1.2em;
}





.NMN_difference_content_line_p{
    text-align: center;
}

.NMN_difference img{
    text-align: center;
    margin: 0 auto;
    width: 100%;
}

.NMN_difference_content_line{
    border: 2px solid #8c7c4d;
    display: inline;
    padding: 3.5em 0 1.5em 0;
}

.NMN_difference_content_back,.line_back{
    background: #f4f4f4;
}

.NMN_difference{
    display: flex;
}

.NMN_difference_title{
    text-align: center;
    margin: 0 auto;
    padding: 1em 0;
}

.NMN_difference_title_small{
    font-size: 0.83334em;
}

.NMN_difference_left_title{
    margin-right: 3.5%;
    color: #8c7c4d;
}

.NMN_difference_right_title{
    margin-left: 3.5%;
    color: #777777;
}

.NMN_difference_left img{
    padding: 1em 1.5em 0.5em 0;
    width: 96%;
}

.NMN_difference_right img{
    padding: 1em 0em 0.5em 1.2em;
    width: 96.4%;
}

.NMN_difference_left{
    border-right: 1px solid #d5d5d5;
}

.NMN_difference_left,.NMN_difference_right{
    text-align: center;
    width: 50%;
}

.NMN_difference_left_title,.NMN_difference_right_title{
    font-size: 2.5em;
    background-color: #fff;
}

.NMN_difference_left_p,.NMN_difference_right_p{
    font-size: 1.875em;
    padding: 0.2em 0;
}

.NMN_difference_right_p_sp{
    padding: 0px;
}

.NMN_difference_right_p_back,.NMN_difference_left_p_back{
    background-color: #fff;
}

.NMN_difference_left_p{
    color: #8c7c4d;
}

.NMN_difference_right_p{
    color: #777777;
}

.NMN_difference_p_up_left{
    padding: 1.5em 0;
}

.NMN_difference_p_up_right{
    padding: 0.5em 0;
}

.NMN_difference_left_p_padding{
    padding: 30px;
}

.difference_summarize_p{
    color: #8c7c4d;
    font-size: 4.5em;
    margin: 0 auto;
    display: block;
    text-align: center;
    padding: 1em 0;
    line-height: 1.3em;
}

.difference_summarize_p_small{
    font-size: 0.833334em;
    font-weight: lighter;
}

.strength-inner{
    margin: 0 auto;
    position: relative;
}

.strength-item{
    margin: 0 auto;
    position: relative;
    display: flex;
}

.headline{
    font-weight: 600;
}

@media screen and (min-width: 700px){
.strength-inner {
    max-width: 1120px;
    margin-top: 10%;
    width:calc(100% - 60px)
}

.strength-item-wrapper {
    margin-top: 40px;
    font-family: "游明朝体" , "YuMincho";
}
.wrapper {
    width: 38.88888888888889vw;
    margin-top: 28px;
}
.content-block {
    padding: 51px 57px 49px 55px;
    margin-top: 30px;
}

.headline{
    margin-top: 19px;
    font-size: 2.5em;
    line-height: 1.333333333333333;
    white-space: pre-line;
}

.description{
    margin-top: 17px;
    line-height: 1.875;
    font-size: 1.625em;
}
}


@media (min-width: 1040px){
.strength-item {
    flex-wrap: nowrap;
    justify-content: space-between;
    align-items: flex-start;
}

.content-block {
    margin-left: 55px;
    width: 50%;
    min-width: 350px;
    margin-top: 0;
}
}

.headline{
    margin-left: auto;
    margin-right: auto;
    font-weight: 600;
    text-align: center;
}




.NMN_effect_content_back{
    background-image: url(images/effect_back_img.png);
    background-size: 100% 100%;
}

.NMN_effect_content{
    color: #fff;
    padding: 5em 0;
    margin: 0 5%;
}

.NMN_effect_content_flex{
    display: flex;
    justify-content: space-between;
}

.NMN_effect_content_right_img{
    width: 40%;
    height: 100%;
    padding-top: 4em;
}

.NMN_effect_content_flex_left_under_p{
    font-size: 1.47368421em;
}

.NMN_effect_content_flex_left_p{
    padding: 0.5em 0 1.5em 0;
}

.NMN_effect_content_flex_left_under_p_padding{
    padding: 0.3em 0;
    max-width: 1000px;
}

.NMN_effect_content_flex_left_under img{
    padding-right: 0.2em;
}





.patient_content_back{
    background: #f0f0f0;
    padding-top: -1em;
}

.patient_content{
    max-width: 1000px;
    margin: 0 auto;
}

.patient_content_title{
    text-align: center;
    padding-top: 1em;
}

.patient_content_title_line{
    border: 2px solid #cdc5ad;
    width: 4em;
    height: 0;
    margin: 0 auto;
}

.patient_content_h3{
    text-align: center;
    font-size: 2em;
    padding-top: 0.2em;
}

.patient_content_h3_2{
    text-align: left;
}

.patient_content_h5{
    font-size: 2.375em;
    color: #aa0000;
}   

.patient_content_h5_number{
    font-size: 1.31578947em;
}  

.patient_voice_up,.patient_voice_down{
    display: flex;
    padding-bottom: 3em;
}

.patient_voice_up{
    padding-left: 3em;
}

.patient_voice_down{
    padding-right: 3em;
}

.patient_voice_p1{
    font-size: 1.75em;
    color: #272727;
    display: flex;
    align-items: center;
}

.patient_voice_p1:after {
    border-top: 1px solid #272727;
    content: "";
    flex-grow: 1;
}
.patient_voice_p1:after {
    margin-left: 1rem;
    background: linear-gradient(90deg, #272727, transparent);
}

.patient_voice_p2{
    font-size: 1.5em;
}

.patient_voice_age{
    font-size: 2.25em;
    color: #8c7c4d;
    padding: 1em 0;
    display: flex;
    align-items: center;
}

.patient_voice_age::before{
    content: '';
    height: 2px;
    background-color: #8c7c4d;
    width: 70px;
}
.patient_voice_age::before {
    margin-right: 1rem;
}

.patient_voice_age:after {
    margin-left: 1rem;
}

.patient_voice_down_left{
    padding-left: 2em;
}

.patient_voice_up_right{
    padding-right: 1em;
}

.patient_img_up{
    height: 100%;
}



.patient_img_down_padding{
    padding-top: 2em;
    height: 100%;
}





.flow_content_back{
    background-image: url(images/flow_back_img.png);
    background-size: 100% 100%;
}

.flow_content{
    margin: 0 auto;
    max-width: 950px;
    padding: 10em 0 3em 0;
}

.flow_content_img{
    display: block;
    margin: 0 auto;
}

.flow_content_h3{
    text-align: center;
    padding: 1em 0;
}

.flow_content_nunber{
    display: flex;
    border-bottom: 1.5px solid #8c7c4d;
}

.flow_content_nunber_right_p_under_line{
    background:linear-gradient(transparent 60%, #fdff74 0%) ;
}

.flow_content_nunber_right_h4{
    font-size: 2.125em;
    padding-bottom: 0.2em;
    text-shadow:0 0 10px #fff;
}

.flow_content_side_line{
    border: 1px solid #aa0000;
    width: 5%;
}

.flow_content_nunber_right_p{
    font-size: 1.625em;
    padding-top: 0.5em;
    text-shadow:0 0 10px #fff;
}

.flow_content_vertical_line_1{
    padding: 3em 0 2em 0;
}

.flow_content_vertical_line_2{
    border-left: 2px solid #aa0000;
    width: 0px;
    height: 2em;
    margin: 0 auto;
}

.flow_content_nunber_img_1{
    padding-right: 3.5em;
}

.flow_content_nunber_img_2{
    padding-right: 2em;
}

.flow_content_nunber_img_3{
    height: 95%;
    margin: auto 0;
    padding-right: 1.8em;
}

.flow_content_nunber_img_4{
    padding-right: 1.5em;
}



.price_content{
    padding-bottom: 8em;
    text-align: center;
    margin: 0 auto;
    max-width: 1100px;
}

.price_content_line{
    border: 2px solid #8c7c4d;
    height: 0;
    width: 3em;
    margin: 0 auto;
}

.price_content_img{
    padding: 5em 0 2em 0;
}

.price_content_h3{
    padding: 1em 0;
}

table{
    border-collapse: collapse;
    text-align: center;
    margin: 0 auto;
    line-height: 1.4;
}

table th, table td {
    border: solid 1px black;
    /*実線 1px 黒*/
}

.price_content_table_tr{
    font-size: 1.875em;
    border-bottom: 4px solid #8c7c4d;
}

.price_content_th_up{
    font-size: 1.875em;
    color: #8c7c4d;
}

.price_content_th_up_side_padding{
    padding: 0 2em;
}

.price_content_th_padding{
    padding: 0 3.1em 0 2.9em;
}

.price_content_tr_big{
    font-size: 1.875em;
}

.price_content_tr_span{
    text-align: center;
    position: absolute;
    top: 89%;
    left: 52%;
    transform: translate(-50%, -50%);
}

.price_content_tr_course{
    font-size: 0.8em;
    margin-left: 4%;
}

.price_content_tr_small{
    font-size: 1.5625em;
    padding: 1em 0;
}

.price_content_tr_big img{
    width: 32%;
    margin-top: 5%;
}

.price_content_tr_small_padding{
    padding: 0.3em 0;
}

.price_content_tr_padding_up{
    padding: 0.8em 0;
}

.price_table_img{
    padding: -0.5em 0 0 -1em;
}

.price_content_table_p{
    padding: 1em 0 0 30em;
    font-size: 1.375em;
}

.price_content_border_300{
    width: 12em;
    text-align: left;
    transform: translate(0, -30%);
}

.price_content_border_up_left{
    border:1px solid; border-color:#fff #000 #000 #fff; 
}

.price_content_border_left{
    border:1px solid; border-color:#000 #000 #000 #fff;
}

.price_content_border_left_under{
    border:1px solid; border-color:#000 #000 #fff #fff;
}

.price_content_border_up{
    border:1px solid; border-color:#fff #000 #000 #000;
}

.price_content_border_under{
    border:1px solid; border-color:#000 #000 #fff #000;
}

.price_content_border_up_right{
    border:1px solid; border-color:#fff #fff #000 #000;
}

.price_content_border_right{
    border:1px solid; border-color:#000 #fff #000 #000;
}

.price_content_border_right_under{
    border:1px solid; border-color:#000 #fff #fff #000;
}




.img{
    width: 100%;
}


.caution{
    text-align: right;
    padding: 0.5em 23em 0 0;
}



.director_content_back{
    background: #eeeeee;
}

.director_content{
    display: flex;
    justify-content: space-between;
    padding: 4em 0 4em 2em;
    position: relative;
}

.director_content_h3{
    border-bottom: 2px solid #8c7c4d;
}

.director_content_p1{
    color: #646464;
    font-size: 2.125em;
    padding: 0.5em 0;
}

.director_content_p2{
    font-size: 1.25em;
}

.director_content_under_p{
    display: flex;
    margin: auto 0;
    padding: 2em 0;
}

.director_content_left{
    width: 60%;
}

.director_content_right{
    width: 45%;
}

.director_p{
    font-size: 1.875em;
    border: 1px solid #8c7c4d;
    padding: 0 0.5em;
    margin: auto 0;
}

.director_name{
    font-size: 2.5em;
    padding: 0 0.5em;
}

.director_neme_inglish{
    font-size: 1.5625em;
    color: #8c7c4d;
    margin: auto 0;
}

.director_img_size{
    width: 100%;
    padding-left: 2em;
}

.director_content_right{
    position: absolute;
    right: -7%;
    top: -2%;
}

.director_img_position_back{
   position: relative;
}

.director_img_position_up{
    position: absolute;
    right: 8%;
    top: 4%;
    width: 28%;
}





.detail_content_back{
    background: #fffbcc;
}

.detail_content{
    display: flex;
    justify-content: space-between;
    max-width: 1100px;
    margin: 0 auto;
    padding: 3.75em;
}

.detail_content_map_widht{
    width: 100%;
}

.detail_content_map{
    width: 45%;
    height: 100%;
}

.detail_content_detail_up{
    display: flex;
    width: 100%;
}

.detail_content_detail_up img{
    height: 100%;
}

.detail_content_detail_up_p{
    text-align: center;
    padding-left: 17%;
}

.detail_content_detail_up_p1{
    font-size: 0.875em;
    font-weight: bold;
}

.detail_content_detail_up_h2{
    font-size: 1.5em;
    line-height: 1.2;
}

.prevention_p{
    color: #fff;
    background: #8c7c4d;
    text-align: center;
    font-weight: bold;
    font-size: 0.75em;
}

.detail_content_detail_under{
    display: flex;
    padding-top: 1em;
}

.detail_content_detail_under img{
    width: 45%;
    height: 90%;
    padding-top: 0.5em;
}


.detail_content_detail_under_right{
    padding-left: 0.5em;
    width: 100%;
}

.detail_content_detail_under_right img{
    width: 6%;
}

.detail_content_detail_under_right_font{
    font-weight: bold;
    line-height: 1.5;
}

.detail_content_p_size{
    font-size: 0.6875em;
    line-height: 1.5;
}

.phone_number{
    font-size: 1.75em;
    line-height: 1.5;
}

.detail_content_p_weight{
    font-weight: bold;
}

.detail_content_p_size_bottom{
    padding-bottom: 1em;
}

.detail_content_detail_under{
    height: 70%;
}




footer{
    background: #bfa043;
}


footer p{
    font-size: 0.75em;
    text-align: center;
    display: block;
    color: #fff;
    padding: 10px 0;
}


.bt_inquiries{
    text-align: center;
    padding: 0% 15%;
    padding-bottom: 2em;
}

.bt_inquiries img{
    max-width: 100%;
    vertical-align: top;
}

.fixed_btn
{
    position: fixed;
    top: 20%;
    right: 10px;
    z-index: 1000;
}

.poyopoyo {
  animation: poyopoyo 2s ease-out infinite;
  opacity: 1;
}
@keyframes poyopoyo {
  0%, 40%, 60%, 80% {
    transform: scale(1.0);
  }
  50%, 70% {
    transform: scale(0.95);
  }
}

.page-link{
    opacity: 1;
    visibility: visible;
    transition: all .2s;
    position: fixed;
    right: calc(50% - 600px);
    transform: translateX(50%);
    bottom: 5%;
}

.page-link img{
    width: 100%;
}


@media screen and (max-width:1435px){
    .page-link{
        right: calc(50% - 530px);
        z-index: 9999;
        visibility: inherit;
        opacity: 1;
    }
}

@media screen and (max-width:1194px){
    .page-link{
        right: calc(50% - 470px);
    }

    .page-link img{
        width: 80%;
    }
}    


@media screen and (max-width:1040px){
    .page-link{
        right: calc(50% - 700px);
    }

    .page-link img{
        width: 50%;
    }
}

@media screen and (max-width:320px){
    .page-link{
        right: calc(50% - 700px);
    }

    .page-link img{
        width: 50%;
    }
}

@media screen and (max-width:300px){
     .page-link{
         right: calc(50% - 700px);
     }

     .page-link img{
         width: 40%;
     }
 }       


 @media screen and (max-width:280px){
     .page-link{
         right: calc(50% - 700px);
     }

     .page-link img{
         width: 40%;
     }
 }





/*------------------------------------------------------------
ANIMATION
------------------------------------------------------------*/

[class*="fadeIn"] {
    visibility: hidden;
}
.fadeIn.show {
    animation-name: fade-in-normal;
    animation-duration: 1.2s;
    visibility: visible;
}
.fadeInFromLeft.show {
    animation-name: fade-in-from-left;
    animation-duration: 1.2s;
    visibility: visible;
}
.fadeInFromRight.show {
    animation-name: fade-in-from-right;
    animation-duration: 1.2s;
    visibility: visible;
}
@keyframes fade-in-normal {
  0% {
    opacity: 0;
    transform: scale(1.1);
  }
  100% {
    opacity: 1;
    transform: scale(1.0);
  }
}
@keyframes fade-in-from-left {
  0% {
    opacity: 0;
    transform: translateX(-30%) scale(1.2);
  }
  100% {
    opacity: 1;
    transform: translateX(0%) scale(1.0);
  }
}
@keyframes fade-in-from-right {
  0% {
    opacity: 0;
    transform: translateX(30%) scale(1.2);
  }
  100% {
    opacity: 1;
    transform: translateX(0%) scale(1.0);
  }
}